• CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques 

      Kok, Eloise H; Luoto, Teemu; Haikonen, Satu; Goebeler, Sirkka; Haapasalo, Hannu; Karhunen, Pekka J (2011)
      article
      Introduction APOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting ...
    • CRP gene variation affects early development of Alzheimer's disease-related plaques 

      Kok, Eloise H; Alanne-Kinnunen, Mervi; Isotalo, Karita; Luoto, Teemu; Haikonen, Satu; Goebeler, Sirkka; Perola, Markus; Hurme, Mikko; Haapasalo, Hannu; Karhunen, Pekka J (2011)
      article
      Introduction We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's ...
    • Health and Illness at the Age of 90 

      Goebeler, Sirkka
      Acta Electronica Universitatis Tamperensis : 919 (Tampere University Press, 2009)
      Väitöskirja
      Väestö ikääntyy nopeasti, ja nopeimmin kasvava ikäryhmä ovat yli 85-vuotiaat. Monet sairaudet yleistyvät iän myötä, mutta arkitieto kertoo hyvin iäkkäiden olevan pääosin hyväkuntoisia ja melko terveitä. Väestötason tietoa ...
    • Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene Is a Risk Factor of Large-Vessel Atherosclerosis Stroke 

      Abboud, Shérine; Karhunen, Pekka J; Lütjohann, Dieter; Goebeler, Sirkka; Luoto, Teemu; Friedrichs, Silvia; Lehtimäki, Terho; Pandolfo, Massimo; Laaksonen, Reijo (2007)
      article
      Background/Purpose Genetic variation in proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been recently identified as an important determinant of plasma LDL-cholesterol and severity of coronary heart disease. ...