• Characterization of Non-Specific Cytotoxic Cell Receptor Protein 1: A New Member of the Lectin-Type Subfamily of F-Box Proteins 

      Kallio, Heini; Tolvanen, Martti; Jänis, Janne; Isola, Jorma (Tay); Kallioniemi, Anne (Tay); Laurila, Eeva (Tay); Pan, Pei-Wen (Tay); Parkkila, Seppo (Tay); Tuominen, Vilppu (Tay); Valjakka, Jarkko (Tay) (2011)
      article
      Our previous microarray study showed that the non-specific cytotoxic cell receptor protein 1 (Nccrp1) transcript is significantly upregulated in the gastric mucosa of carbonic anhydrase IX (CA IX)-deficient (Car9−/−) mice. ...
    • Expression of carbonic anhydrases IX and XII during mouse embryonic development 

      Kallio, Heini; Pastorekova, Silvia; Pastorek, Jaromir; Waheed, Abdul; Sly, William S; Männistö, Susanna; Heikinheimo, Markku; Parkkila, Seppo (2006)
      article
      Background Of the thirteen active carbonic anhydrase (CA) isozymes, CA IX and XII have been linked to carcinogenesis. It has been suggested that these membrane-bound CAs participate in cancer cell invasion, which is ...
    • Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach 

      Kallio, Heini; Hilvo, Mika; Rodriguez, Alejandra; Lappalainen, Eeva-Helena; Lappalainen, Anna-Maria; Parkkila, Seppo (2010)
      article
      Background Carbonic anhydrases (CAs) are a family of enzymes that regulate pH homeostasis in various tissues. CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated ...
    • Integrated clinical, whole genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer 

      Bova, Stephen G; Kallio, Heini; Annala, Matti; Kivinummi, Kati; Högnäs, Gunilla; Häyrynen, Sergei; Rantapero, Tommi; Kivinen, Virpi; Isaacs, William; Tolonen, Teemu; Nykter, Matti; Visakorpi, Tapio (2016)
      article
      We report the first combined analysis of whole-genome sequence, detailed clinical history, and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). Whole-genome and transcriptome sequence ...
    • Regulation and Roles of Carbonic Anhydrases IX and XII 

      Kallio, Heini
      Acta Electronica Universitatis Tamperensis : 1139 (Tampere University Press, 2011)
      Väitöskirja
      Hiilihappoanhydraasi-entsyymit osallistuvat pH-tasapainon säätelyyn solujen, kudosten ja koko elimistön tasolla. Nämä entsyymit katalysoivat reaktiota, jossa hiilidioksidi ja vesi muuttuvat bikarbonaatiksi ja vetyioniksi. ...
    • Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors 

      Järvelä, Sally; Rantala, Immo; Rodriguez, Alejandra; Kallio, Heini; Parkkila, Seppo; Kinnula, Vuokko L; Soini, Ylermi; Haapasalo, Hannu (2010)
      article
      Background Peroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis. Methods We studied the expression of Prx I-VI and their relationship to patient survival in 383 grade II-IV diffuse astrocytic ...