• Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation 

      Tukiainen, Taru; Pirinen, Matti; Sarin, Antti-Pekka; Landenvall, Claes; Kettunen, Johannes; Lehtimäki, Terho; Lokki, Marja-Liisa; Perola, Markus; Sinisalo, Juha; Vlachopoulou, Efthymia; Eriksson, Johan; Groop, Leif; Jula, Antti; Järvelin, Marjo-Riitta; Raitakari, Olli; Salomaa, Veikko; Ripatti, Samuli (2014)
      article
      The X chromosome (chrX) represents one potential source for the “missing heritability” for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the ...
    • Common Genetic Variants Associated with Sudden Cardiac Death : The FinSCDgen Study 

      Lahtinen, Annukka; Noseworthy, Peter A; Havulinna, Aki S; Jula, Antti; Karhunen, Pekka J; Kettunen, Johannes; Perola, Markus; Kontula, Kimmo; Newton-Cheh, Christopher; Salomaa, Veikko (2012)
      article
      Background Sudden cardiac death (SCD) accounts for up to half of cardiac mortality. The risk of SCD is heritable but the underlying genetic variants are largely unknown. We investigated whether common genetic variants ...
    • CRP gene variation affects early development of Alzheimer's disease-related plaques 

      Kok, Eloise H; Alanne-Kinnunen, Mervi; Isotalo, Karita; Luoto, Teemu; Haikonen, Satu; Goebeler, Sirkka; Perola, Markus; Hurme, Mikko; Haapasalo, Hannu; Karhunen, Pekka J (2011)
      article
      Introduction We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's ...
    • Genetic causal beliefs about morbidity: associations with health behaviors and health outcome beliefs about behavior changes between 1982–2002 in the Finnish population 

      Haukkala, Ari; Konttinen, Hanna; Hankonen, Nelli; Perola, Markus; Kääriäinen, Helena; Salomaa, Veikko (2015)
      article
      Background The role and meaning of genetic information has grown considerably in the recent decades. We examined changes in causal beliefs about morbidity as well as the associations between causal beliefs, health ...
    • Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population 

      Salo, Perttu; Vaara, Satu; Kettunen, Johannes; Pirinen, Matti; Sarin, Antti-Pekka; Huikuri, Heikki; Karhunen, Pekka J; Eskola, Markku; Nikus, Kjell; Lokki, Marja-Liisa; Ripatti, Samuli; Havulinna, Aki; Salomaa, Veikko; Palotie, Aarno; Nieminen, Markku S; Sinisalo, Juha; Perola, Markus (2015)
      article
      Myocardial infarction (MI) is divided into either ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI), differing in a number of clinical characteristics. We sought to identify genetic variants conferring risk to NSTEMI ...
    • Genome-Wide Meta-Analysis of Sciatica in Finnish Population 

      Lemmelä, Susanna; Solovieva, Svetlana; Rahman, Shiri; Benner, Christian; Heliövaara, Markku; Kettunen, Johannes; Anttila, Vemeri; Ripatti, Samuli; Perola, Markus; Seppälä, Ilkka; Juonala, Markus; Kähönen, Mika; Salomaa, Veikko; Viikari, Jorma; Raitakari, Olli; Lehtimäki, Terho; Palotie, Aarno; Viikari-Juntura, Eira; Husgafvel-Pursiainen, Kirsti (2016)
      article
      Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is ...