• Construction of Chimeric Dual-Chain Avidin by Tandem Fusion of the Related Avidins 

      Riihimäki, Tiina A; Kukkurainen, Sampo; Varjonen, Suvi; Hörhä, Jarno; Nyholm, Thomas KM; Kulomaa, Markku S; Hytönen, Vesa P (2011)
      article
      Background Avidin is a chicken egg-white protein with high affinity to vitamin H, also known as D-biotin. Many applications in life science research are based on this strong interaction. Avidin is a homotetrameric protein, ...
    • Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein 

      Riihimäki, Tiina A; Hiltunen, Soili; Rangl, Martina; Nordlund, Henri R; Määttä, Juha A E; Ebner, Andreas; Hinterdorfer, Peter; Kulomaa, Markku S; Takkinen, Kristiina; Hytönen, Vesa P (2011)
      article
      Background Engineered proteins, with non-immunoglobulin scaffolds, have become an important alternative to antibodies in many biotechnical and therapeutic applications. When compared to antibodies, tailored proteins may ...