TamPub - Selaus tekijän mukaan "Adcock, Ian"

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Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

Kankaanranta, Hannu; Janka-Junttila, Mirkka; Ilmarinen-Salo, Pinja; Ito, Kazuhiro; Jalonen, Ulla; Ito, Misako; Adcock, Ian; Moilanen, Eeva; Zhang, Xianzhi (2010)
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Background Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) ...
The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils

Janka-Junttila, Mirkka; Moilanen, Eeva; Hasala, Hannele; Zhang, Xianzhi; Adcock, Ian; Kankaanranta, Hannu (2006)
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Background Glucocorticoids are used to treat chronic inflammatory diseases such as asthma. Induction of eosinophil apoptosis is considered to be one of the main mechanisms behind the anti-asthmatic effect of glucocorticoids. ...
Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1

Kankaanranta, Hannu; Ilmarinen, Pinja; Zhang, Xianzhi; Adcock, Ian; Lahti, Aleksi; Barnes, Peter; Giembycz, Mark; Lindsay, Mark; Moilanen, Eeva (2014)
article

Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils. In contrast to Fas, TNF-α inhibited ...