• Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry 

      Wirtz, Ralph M; Sihto, Harri; Isola, Jorma; Heikkilä, Päivi; Kellokumpu-Lehtinen, Pirkko-Liisa; Auvinen, Päivi; Turpeenniemi-Hujanen, Taina; Jyrkkiö, Sirkku; Lakis, Sotiris; Schlombs, Kornelia; Laible, Mark; Weber, Stefan; Eidt, Sebastian; Sahin, Ugur; Joensuu, Heikki (2016)
      The biological subtype of breast cancer influences the selection of systemic therapy. Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but substantial intra-observer and inter-observer ...
    • Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer 

      Sonnenblick, Amir; Brohée, Sylvain; Fumagalli, Debora; Vincent, Delphine; Venet, David; Ignatiadis, Michail; Saldago, Robert; Van den Eynden, Gert; Rothé, Francoise; Desmedt, Christine; Neven, Patrik; Loibl, Sibylle; Denkert, Carsten; Joensuu, Heikki; Loi, Sherene; Sirtaine, Nicolas; Kellokumpu-Lehtinen, Pirkko-Liisa; Piccart, Martine; Sotiriou, Christos (2015)
      Background The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator ...
    • Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer 

      Konsti, Juho; Lundin, Mikael; Joensuu, Heikki; Holli, Kaija (Tay); Isola, Jorma (Tay) (2011)
      Background The aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients ...
    • Human breast cancer cells educate macrophages toward the M2 activation status 

      Sousa, Sofia; Brion, Régis; Lintunen, Minnamaija; Kronqvist, Pauliina; Sandholm, Jouko; Mönkkönen, Jukka; Kellokumpu-Lehtinen, Pirkko-Liisa; Lauttia, Susanna; Tynninen, Olli; Joensuu, Heikki; Heymann, Dominique; Määttä, Jorma (2015)
      Abstract Introduction The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there is usually a correlation between the ...
    • Long-term prognosis of breast cancer detected by mammography screening or other methods 

      Lehtimäki, Tiina; Lundin, Mikael; Linder, Nina; Sihto, Harri; Holli, Kaija; Turpeenniemi-Hujanen, Taina; Kataja, Vesa; Isola, Jorma; Joensuu, Heikki; Lundin, Johan (2011)
      Introduction Previous studies on breast cancer have shown that patients whose tumors are detected by mammography screening have a more favorable survival. However, little is known about the long-term prognostic impact of ...
    • Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription 

      Kaukonen, Riina; Mai, Anja; Georgiadou, Maria; Saari, Markku; De Franceschi, Nicola; Betz, Timo; Sihto, Harri; Ventelä, Sami; Elo, Laura; Jokitalo, Eija; Westermarck, Jukka; Kellokumpu-Lehtinen, Pirkko-Liisa; Joensuu, Heikki; Grenman, Reidar; Ivaska, Johanna (2016)
      Tissue homeostasis is dependent on the controlled localization of specific cell types and the correct composition of the extracellular stroma. While the role of the cancer stroma in tumour progression has been well ...
    • Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanne 

      Holmström, Oscar; Linder, Nina; Lundin, Mikael; Moilanen, Hannu; Suutala, Antti; Turkki, Riku; Joensuu, Heikki; Isola, Jorma; Diwan, Vinod; Lundin, Johan (2015)
      A significant barrier to medical diagnostics in low-resource environments is the lack of medical care and equipment. Here we present a low-cost, cloud-connected digital microscope for applications at the point-of-care. We ...
    • Trastuzumab emtansine: mechanisms of action and drug resistance 

      Barok, Mark; Joensuu, Heikki; Isola, Jorma (2014)
      Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that is effective and generally well tolerated when administered as a single agent to treat advanced breast cancer. Efficacy has now been demonstrated in randomized ...