TamPub - Selaus tekijän mukaan "Koskinen, Marja-Leena"
Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose Yang, Runkuan; Zou, Xiaoping; Koskinen, Marja-Leena; Tenhunen, Jyrki (2012)
articleIntroduction Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early ...
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity Yang, Runkuan; Zou, Xiaoping; Tenhunen, Jyrki; Zhu, Shengtao; Kajander, Henri; Koskinen, Marja-Leena; Tonnessen, Tor Inge (2014)
articleBackground Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte ...
Yang, Runkuan; Zhang, Shutian; Kajander, Henri; Zhu, Shengtao; Koskinen, Marja-Leena; Tenhunen, Jyrki (2011)
articleBackground Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration ...