TamPub - Selaus tekijän mukaan "Tammela, Teuvo"
Viitteet 1-20 / 35
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Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
(2012)
articleBackground Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and ... -
Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer : statistical evaluation of epistasis
(2014)
articleUnderstanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the ... -
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
(2016)
articleAlthough genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ... -
Enzalutamide in metastatic prostate cancer before chemotherapy
(2014)
articleBACKGROUND: Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy. New treatment ... -
Epigenetically altered miR-193b targets cyclin D1 in prostate cancer
(2015)
articleMicro-RNAs (miRNA) are important regulators of gene expression and often differentially expressed in cancer and other diseases. We have previously shown that miR-193b is hypermethylated in prostate cancer (PC) and suppresses ... -
Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer
(2015)
articleThe 2q37 and 17q12-q22 loci are linked to an increased prostate cancer (PrCa) risk. No candidate gene has been localized at 2q37 and the HOXB13 variant G84E only partially explains the linkage to 17q21-q22 observed in ... -
Ikääntyvän miehen seksuaalisuus ja sen häiriöt
(2009)
articleIkääntyvän miehen seksuaalinen toimintakyky heikkenee mutta vähemmän kuin on oletettu. Myös seksuaalinen halu säilyy pitkään. Tavallisimmat häiriöt ovat erektiokyvyn heikkeneminen ja ejakulaation häiriöt. Virtsaamisoireilla ... -
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND)
(2016)
articleBACKGROUND: Intermittent androgen deprivation (IAD) has received increasing attention; however, the current literature is still limited, especially in nonmetastatic prostate cancer (PCa), and the relative efficacy and ... -
Is the Prevalence of Overactive Bladder Overestimated? A Population-Based Study in Finland
(2007)
articleBackground In earlier studies, one in six adults had overactive bladder which may impair quality of life. However, earlier studies have either not been population-based or have suffered from methodological limitations. ... -
Kannattaako eturauhassyöpää seuloa?
(2009)
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Kastraation luustovaikutukset eturauhassyöpäpotilailla
(2011)
articleLevinneen eturauhassyövän hoitona käytetään yleisesti kirurgista tai kemiallista kastraatiota. Kastraation tavallisia haittavaikutuksia ovat hikoilu, kuumat aallot ja punoitus kasvoissa, painon ja rasvan lisääntyminen, ... -
Mapping of the chromosomal amplification 1p21-22 in bladder cancer
(2014)
articleBackground The aim of the study was to characterize a recurrent amplification at chromosomal region 1p21-22 in bladder cancer. Methods ArrayCGH (aCGH) was performed to identify DNA copy number variations in 7 clinical ... -
Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer
(2016)
articleMicroseminoprotein-beta (MSMB, MSMB) is an abundant secretory protein contributed by the prostate, and is implicated as a prostate cancer (PC) biomarker based on observations of its lower expression in cancerous cells ... -
MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families
(2015)
articleBACKGROUND: Heritable factors are evidently involved in prostate cancer (PrCa) carcinogenesis, but currently, genetic markers are not routinely used in screening or diagnostics of the disease. More precise information ... -
Mitä lääkärin ja potilaan tulee tietää eturauhassyövän seulonnasta?
(2015)
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NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene
(2011)
articleBackground Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been ...
