• High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity 

      Yang, Runkuan; Zhang, Shutian; Cotoia, Antonella; Oksala, Niku; Zhu, Shengtao; Tenhunen, Jyrki (2012)
      article
      Background Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect ...
    • Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity 

      Yang, Runkuan; Zhang, Shutian; Kajander, Henri; Zhu, Shengtao; Koskinen, Marja-Leena; Tenhunen, Jyrki (2011)
      article
      Background Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration ...