• A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster 

      Ekström, Jens-Ola; Hultmark, Dan (2016)
      article
      We have created a transgenic reporter for virus infection, and used it to study Nora virus infection in Drosophila melanogaster. The transgenic construct, Munin, expresses the yeast transcription factor Gal4, tethered to ...
    • Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses 

      van Mierlo, Joel; Bronkhorst, Alfred; Overheul, Gijs; Sadanandan, Sajna; Ekström, Jens-Ola; Heestermans, Marco; Hultmark, Dan; Antoniewski, Chistophe; van Rij, Ronald (2012)
      article
      RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi. We detected viral small RNAs ...
    • Nora Virus Persistent Infections Are Not Affected by the RNAi Machinery 

      Habayeb, Mazen S; Ekström, Jens-Ola; Hultmark, Dan (2009)
      article
      Drosophila melanogaster is widely used to decipher the innate immune system in response to various pathogens. The innate immune response towards persistent virus infections is among the least studied in this model system. ...
    • VP3 is crucial for the stability of Nora virus virions 

      Sadanandan, Sajna Anand; Ekström, Jens-Ola; Venkateswara Rao, Jonna; Hultmark, Dan; Hofer, Anders (2016)
      article
      Nora virus is an enteric virus that causes persistent, non-pathological infection in Drosophila melanogaster. It replicates in the fly gut and is transmitted via the fecal-oral route. Nora virus has a single-stranded ...