A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983 2003

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dc.contributor.author Lyytikäinen, Erika -
dc.contributor.author Kaasila, Marjo -
dc.contributor.author Hiltunen-Back, Eija -
dc.contributor.author Lehtinen, Matti -
dc.contributor.author Tasanen, Kaisa -
dc.contributor.author Surcel, Heljä-Marja -
dc.contributor.author Koskela, Pentti -
dc.contributor.author Paavonen, Jorma -
dc.date.accessioned 2012-06-17T20:13:46Z
dc.date.available 2012-06-15 06:18:27 -
dc.date.available 2012-06-17T20:13:46Z
dc.date.issued 2008 -
dc.identifier.issn 1471-2334 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65795
dc.description BioMed Central Open access -
dc.description.abstract Background Reported rates of Chlamydia trachomatis are on the rise contradicting the declining rates of C. trachomatis associated reproductive sequelae in Western countries. Population based evaluation of the real trend of C. trachomatis infection is important to contemplate prevention efforts. We studied C. trachomatis occurrence during the past 20 years in Finland comparing incidence rate data based on serology and reported C. trachomatis laboratory notifications. Methods A random sample of 7999 women with two consecutive pregnancies within five years was selected from the population of the Finnish Maternity Cohort (FMC) serum bank stratified by calendar year and age. C. trachomatis IgG antibodies were determined by a standard peptide-ELISA. The reported incidence rates of C. trachomatis infections based on case notifications were obtained from the National Registry of Infectious Diseases (NIDR). Results C. trachomatis seroprevalence rates decreased significantly from 1983 to 2003 both in women under 23 years of age (23.3% to 9.2%) and in women between 23–28-years of age (22.2% to 12.6%). However, seroconversion rates increased from 31 per 10000 person years in 1983–85 to 97 per 10000 person years in 2001–2003 (incidence rate ratio 3.2, 95% CI, 1.1–8.7) among the older age group. Seroconversion rate was highest (264) in 1983–1985 in the younger age-group, then declined and subsequently increased again (188) in 2001–2003. The incidence based on seroconversions was in agreement with the reported incidence rates in both age groups. Conclusion C. trachomatis seroprevalence rate decreased during 1983–2003 among fertile-aged women in Finland. During the same time period incidence rates based both on seroconversions and reported laboratory notifications of diagnosed C. trachomatis infections increased. The discrepancy between the C. trachomatis incidence and seroprevalence trends warrants further studies. -
dc.language.iso en -
dc.title A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983 2003 -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-561 -
dc.identifier.doi 10.1186/1471-2334-8-169 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Terveystiede | en=Health care science| -
dc.journal.title BMC Infectious Diseases -
dc.journal.volume 8 -
dc.journal.number 169 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 62 -

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