Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study


Näytä suppeat kuvailutiedot Service, Helena M - Hintsanen, Mirka - Hintsa, Taina - Lehtimäki, Terho - Raitakari, Olli T - Viikari, Jorma S - Keltikangas-Järvinen, Liisa - 2012-06-17T20:13:47Z 2012-06-16 13:31:54 - 2012-06-17T20:13:47Z 2008 -
dc.identifier.issn 1744-9081 -
dc.description BioMed Central Open access -
dc.description.abstract Background Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior. Methods The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later. Results Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others. Conclusion Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed. -
dc.language.iso en -
dc.title Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-565 -
dc.identifier.doi 10.1186/1744-9081-4-40 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.journal.title Behavioral and Brain Functions -
dc.journal.volume 4 -
dc.journal.number 40 -
dc.journal.volumepagerange 1-5 -
dc.oldstats 59 -

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