PseudoGeneQuest Service for identification of different pseudogene types in the human genome

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dc.contributor.author Ortutay, Csaba -
dc.contributor.author Vihinen, Mauno -
dc.date.accessioned 2012-06-17T20:13:49Z
dc.date.available 2012-06-05 23:53:31 -
dc.date.available 2012-06-17T20:13:49Z
dc.date.issued 2008 -
dc.identifier.issn 1471-2105 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65807
dc.description BioMed Central Open access -
dc.description.abstract Background Pseudogenes, nonfunctional copies of genes, evolve fast due the lack of evolutionary pressures and thus appear in several different forms. PseudoGeneQuest is an online tool to search the human genome for a given query sequence and to identify different types of pseudogenes as well as novel genes and gene fragments. Description The service can detect pseudogenes, that have arisen either by retrotransposition or segmental genome duplication, many of which are not listed in the public pseudogene databases. The service has a user-friendly web interface and uses a powerful computer cluster in order to perform parallel searches and provide relatively fast runtimes despite exhaustive database searches and analyses. Conclusion PseudoGeneQuest is a versatile tool for detecting novel pseudogene candidates from the human genome. The service searches human genome sequences for five types of pseudogenes and provides an output that allows easy further analysis of observations. In addition to the result file the system provides visualization of the results linked to Ensembl Genome Browser. PseudoGeneQuest service is freely available. -
dc.language.iso en -
dc.title PseudoGeneQuest Service for identification of different pseudogene types in the human genome -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-572 -
dc.identifier.doi 10.1186/1471-2105-9-299 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title BMC Bioinformatic -
dc.journal.volume 9 -
dc.journal.number 299 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 47 -

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