Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men

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dc.contributor.author Kiviniemi, Tuomas O -
dc.contributor.author Saraste, Antti -
dc.contributor.author Toikka, Jyri O -
dc.contributor.author Saraste, Markku -
dc.contributor.author Raitakari, Olli T -
dc.contributor.author Pärkkä, Jussi P -
dc.contributor.author Lehtimäki, Terho -
dc.contributor.author Hartiala, Jaakko J -
dc.contributor.author Viikari, Jorma -
dc.contributor.author Koskenvuo, Juha W -
dc.date.accessioned 2012-06-17T20:13:50Z
dc.date.available 2012-06-16 13:37:10 -
dc.date.available 2012-06-17T20:13:50Z
dc.date.issued 2008 -
dc.identifier.issn 1476-7120 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65809
dc.description BioMed Central Open access -
dc.description.abstract Background The cardioprotective effects of certain alcoholic beverages are partly related to their polyphenol content, which may improve the vasodilatory reactivity of arteries. Effect of cognac on coronary circulation, however, remains unknown. The purpose of this randomized controlled cross-over study was to determine whether moderate doses of cognac improve coronary reactivity as assessed with cold pressor testing (CPT) and coronary flow reserve (CFR) measument. Methods Study group consisted of 23 subjects. Coronary flow velocity and epicardial diameter was assessed using transthoracic echocardiography at rest, during CPT and adenosine infusion-derived CFR measurements before drinking, after a moderate (1.2 ± 0.1 dl) and an escalating high dose (total amount 2.4 ± 0.3 dl) of cognac. To explore the bioavailability of antioxidants, the antioxidant contents of cognac was measured and the absorption from the digestive tract was verified by plasma antioxidant capacity determination. Results Serum alcohol levels increased to 1.2 ± 0.2‰ and plasma antioxidant capacity from 301 ± 43.9 μmol/l to 320 ± 25.0 μmol/l by 7.6 ± 11.8%, (p = 0.01) after high doses of cognac. There was no significant change in flow velocity during CPT after cognac ingestion compared to control day. CFR was 4.4 ± 0.8, 4.1 ± 0.9 (p = NS), and 4.5 ± 1.2 (p = NS) before drinking and after moderate and high doses on cognac day, and 4.5 ± 1.4, and 4.0 ± 1.2 (p = NS) on control day. Conclusion Cognac increased plasma antioxidant capacity, but it had no effect on coronary circulation in healthy young men. -
dc.language.iso en -
dc.title Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-574 -
dc.identifier.doi 10.1186/1476-7120-6-25 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.journal.title Cardiovascular Ultrasound -
dc.journal.volume 6 -
dc.journal.number 25 -
dc.journal.volumepagerange 1-9 -
dc.oldstats 68 -

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