Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia

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dc.contributor.author Huttunen, Reetta -
dc.contributor.author Laine, Janne -
dc.contributor.author Lumio, Jukka -
dc.contributor.author Vuento, Risto -
dc.contributor.author Syrjänen, Jaana -
dc.date.accessioned 2012-06-17T20:14:04Z
dc.date.available 2012-06-17 09:27:12 -
dc.date.available 2012-06-17T20:14:04Z
dc.date.issued 2007 -
dc.identifier.issn 1471-2334 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65849
dc.description BioMed Central Open access -
dc.description.abstract Background Bacteraemia is still a major cause of case fatality in all age groups. Our aim was to identify the major underlying conditions constituting risk factors for case fatality in bacteraemia patients. Methods The study involved 149 patients (79 male and 70 female) with bacteraemia caused by Staphylococcus aureus (S. aureus) (41 patients), Streptococcus pneumoniae (Str. pneumoniae) (42 patients), β-hemolytic streptococcae (β-hml str.) (23 patients) and Eschericia coli (E. coli) (43 patients). Underlying diseases, alcohol and tobacco consumption and body mass index (BMI) were registered. Laboratory findings and clinical data were registered on admission and 6 consecutive days and on day 10–14. Case fatality was studied within 30 days after positive blood culture. Associations between underlying conditions and case fatality were studied in univariate analysis and in a multivariate model. Results Nineteen patients (12.8%) died of bacteraemia. We found obesity (p = 0.002, RR 9.8; 95% CI 2.3 to 41.3), smoking (p < 0.001, RR 16.9; 95% CI 2.1 to 133.5), alcohol abuse (p = 0.008, RR 3.9; 95% CI 1.3 to 11.28), COPD (p = 0.01, RR 8.4; 95% CI 1.9 to 37.1) and rheumatoid arthritis (p = 0.045, RR 5.9; 95% CI 1.2 to 28.8) to be significantly associated with case fatality in bacteraemia in univariate model. The median BMI was significantly higher among those who died compared to survivors (33 vs. 26, p = 0.003). Obesity and smoking also remained independent risk factors for case fatality when their effect was studied together in a multivariate model adjusted with the effect of alcohol abuse, age (continuos variable), sex and causative organism. Conclusion Our results indicate that obesity and smoking are prominent risk factors for case fatality in bacteraemic patients. Identification of risk factors underlying fatal outcome in bacteraemia may allow targeting of preventive efforts to individuals likely to derive greatest potential benefit. -
dc.language.iso en -
dc.title Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-611 -
dc.identifier.doi 10.1186/1471-2334-7-13 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.journal.title BMC Infectious Diseases -
dc.journal.volume 7 -
dc.journal.number 13 -
dc.journal.volumepagerange 1-8 -
dc.oldstats 60 -

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