Add- on- therapy options inasthma not adequately controlled by inhaled corticosteroids: a comprehensive review

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dc.contributor.author Kankaanranta, Hannu -
dc.contributor.author Lahdensuo, Aarne -
dc.contributor.author Moilanen, Eeva -
dc.contributor.author Barnes, Peter J -
dc.date.accessioned 2012-06-17T20:14:06Z
dc.date.available 2012-06-16 09:08:24 -
dc.date.available 2012-06-17T20:14:06Z
dc.date.issued 2004 -
dc.identifier.issn 1465-9921 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65857
dc.description BioMed Central open access -
dc.description.abstract Abstract Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to identify randomised and blinded trials. To demonstrate the benefit that can be obtained by increasing the dose of ICS, dose-response studies with at least three different ICS doses were identified. To demonstrate whether more benefit can be obtained by adding long-acting β2-agonist (LABA), leukotriene antagonist (LTRA) or theophylline than by increasing the dose of ICS, studies comparing these options were identified. Thirdly, studies comparing the different "add-on" options were identified. The addition of a LABA is more effective than increasing the dose of ICS in improving asthma control. By increasing the dose of ICS, clinical improvement is likely to be of small magnitude. Addition of a LTRA or theophylline to the treatment regimen appears to be equivalent to doubling the dose of ICS. Addition of a LABA seems to be superior to an LTRA in improving lung function. However, addition of LABA and LTRA may be equal with respect to asthma exacerbations. However, more and longer studies are needed to better clarify the role of LTRAs and theophylline as add-on therapies. Keywords: Asthma; inhaled corticosteroids; long-acting β2-agonists; theophylline; leukotriene antagonists -
dc.language.iso en -
dc.title Add- on- therapy options inasthma not adequately controlled by inhaled corticosteroids: a comprehensive review -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-618 -
dc.identifier.doi 10.1186/1465-9921-5-17 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title Respiratory Research -
dc.journal.volume 5 -
dc.journal.number 17 -
dc.journal.volumepagerange 1-25 -
dc.oldstats 63 -

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