Low avidity of human papillomavirus (HPV) type 16 antibodies is associated with increased risk of low-risk but not high-risk HPV type prevalence

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dc.contributor.author Hedman, Lea -
dc.contributor.author Hedman, Klaus -
dc.contributor.author Banura, Cecily -
dc.contributor.author Namujju, Proscovia B (Tay) -
dc.contributor.author Lehtinen, Matti (Tay) -
dc.date.accessioned 2012-06-17T20:14:12Z
dc.date.available 2012-06-13 18:52:07 -
dc.date.available 2012-06-17T20:14:12Z
dc.date.issued 2011 -
dc.identifier.issn 1756-0500 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65875
dc.description BioMed Central Open access -
dc.description.abstract Background Low avidity of antibodies against viral, bacterial and parasitic agents has been used for differential diagnosis of acute versus recent/past infections. The low-avidity antibodies may however, persist for a longer period in some individuals. Findings We studied the association of human papillomavirus (HPV) type 16 antibody avidity with seroprevalence to HPV types 6/11/18/31/33/45. Antibody avidity was analysed for 365 HPV16 seropositive pregnant Finnish and Ugandan women using a modified ELISA. Low avidity of HPV16 antibodies was found in 15% of Finnish and 26% of Ugandan women. Ugandan women with low-avidity HPV16 antibodies had an increased risk estimate for HPV6/11 (odds ratio, OR 2.9; 95%CI 1.01-8.4) seropositivity but not to high-risk HPV types 18/31/33/45. Conclusion Association of the low avidity HPV16 antibody "phenotype" with possible susceptibility to infections with other HPV types warrants investigation. -
dc.language.iso en -
dc.title Low avidity of human papillomavirus (HPV) type 16 antibodies is associated with increased risk of low-risk but not high-risk HPV type prevalence -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-656 -
dc.identifier.doi 10.1186/1756-0500-4-170 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Terveystiede | en=Health care science| -
dc.administrativeunit fi=Terveystieteiden yksikkö | en=School of Health Sciences| -
dc.journal.title BMC Research Notes -
dc.journal.volume 4 -
dc.journal.number 170 -
dc.journal.volumepagerange 1-5 -
dc.oldstats 54 -

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