HDL enhances oxidation of LDL in vitro in both men and women

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dc.contributor.author Solakivi, Tiina -
dc.contributor.author Jaakkola, Olli -
dc.contributor.author Salomäki, Anne -
dc.contributor.author Peltonen, Nina -
dc.contributor.author Metso, Saara -
dc.contributor.author Lehtimäki, Terho -
dc.contributor.author Jokela, Hannu -
dc.contributor.author Nikkari, Seppo -
dc.date.accessioned 2012-06-17T20:14:14Z
dc.date.available 2012-06-16 09:11:13 -
dc.date.available 2012-06-17T20:14:14Z
dc.date.issued 2005 -
dc.identifier.issn 1476-511X -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65881
dc.description BioMed Central Open access -
dc.description.abstract Background Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. Some in vitro experiments have previously suggested that high-density lipoprotein (HDL) co-incubated with LDL prevents Cu2+-induced oxidation of LDL, while some other studies have observed an opposite effect. To comprehensively clarify the role of HDL in this context, we isolated LDL, HDL2 and HDL3 from sera of 61 free-living individuals (33 women and 28 men). Results When the isolated LDL was subjected to Cu2+-induced oxidation, both HDL2 and HDL3 particles increased the rate of appearance and the final concentration of conjugated dienes similarly in both genders. Oxidation rate was positively associated with polyunsaturated fatty acid content of the lipoproteins in that it was positively related to the content of linoleate and negatively related to oleate. More saturated fats thus protected the lipoproteins from damage. Conclusion We conclude that in vitro HDL does not protect LDL from oxidation, but is in fact oxidized fastest of all lipoproteins due to its fatty acid composition, which is oxidation promoting. -
dc.language.iso en -
dc.title HDL enhances oxidation of LDL in vitro in both men and women -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-641 -
dc.identifier.doi 10.1186/1476-511X-4-25 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title Lipids in Health and Disease -
dc.journal.volume 4 -
dc.journal.number 25 -
dc.journal.volumepagerange 1-7 -
dc.oldstats 56 -

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