Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration

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dc.contributor.author Solakivi, Tiina -
dc.contributor.author Jaakkola, Olli -
dc.contributor.author Kalela, Anne -
dc.contributor.author Pispa, Mari -
dc.contributor.author Salomäki, Anne -
dc.contributor.author Lehtimäki, Terho -
dc.contributor.author Höyhtyä, Matti -
dc.contributor.author Jokela, Hannu -
dc.contributor.author Nikkari, Seppo T -
dc.date.accessioned 2012-06-17T20:14:15Z
dc.date.available 2012-06-16 09:13:04 -
dc.date.available 2012-06-17T20:14:15Z
dc.date.issued 2005 -
dc.identifier.issn 1476-511X -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65885
dc.description BioMed Central Open access -
dc.description.abstract Background Polyunsaturated fatty acids (PUFA) are thought to play important roles in inflammation. The n-3 series is considered as anti-inflammatory, and some studies have reported increased plasma n-3 polyunsaturated fatty acid pattern in chronic inflammatory conditions. In this study we sought to clarify relationships of the levels of arachidonic acid and the polyunsaturated n-3 fatty acid compositions of isolated LDL, HDL2 and HDL3 particles with matrix metalloproteinase-9 (MMP-9), a marker of inflammation. Results The subjects were divided into two groups: those with lower and those with higher than the median serum MMP-9 concentration. In all lipoprotein fractions, the mean percentage of docosapentaenoic acid (C22:5n-3) was higher in the group of subjects with higher MMP-9 level than in those with lower serum MMP-9 concentration (P < 0.01 for all). Likewise, the ratio of docosapentaenoic acid to arachidonic acid (C20:4n-6) was higher in the subjects with higher MMP-9 compared with the lower MMP-9 group (P < 0.001 for all). Conclusion So far, the evidence for an anti-inflammatory role of the n-3 PUFA has come from dietary interventions. Our results were obtained from a free-living population and indicate that there is a positive correlation between n-3 docosapentaenoic acid and MMP-9. What had triggered the rise in MMP-9 is not known, since serum level of MMP-9 is raised in many inflammatory conditions. These findings may indicate an increased biosynthesis of n-3 polyunsaturated fatty acids in subclinical inflammation. -
dc.language.iso en -
dc.title Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-645 -
dc.identifier.doi 10.1186/1476-511X-4-8 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title Lipids in Health and Disease -
dc.journal.volume 4 -
dc.journal.number 8 -
dc.journal.volumepagerange 1-5 -
dc.oldstats 62 -

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