Who wants to join preventive trials? Experience from the Estonian Postmenopausal Hormone Therapy Trial [ISRCTN35338757]

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dc.contributor.author Hovi, Sirkka-Liisa -
dc.contributor.author Hakama, Matti -
dc.contributor.author Veerus, Piret -
dc.contributor.author Rahu, Mati -
dc.contributor.author Hemminki, Elina -
dc.date.accessioned 2012-06-17T20:14:15Z
dc.date.available 2012-06-16 09:13:32 -
dc.date.available 2012-06-17T20:14:15Z
dc.date.issued 2005 -
dc.identifier.issn 1471-2288 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65886
dc.description BioMed Central Open access -
dc.description.abstract Background The interest of patients in participating in randomized clinical trials involving treatments has been widely studied, but there has been much less research on interest in preventive trials. The objective of this study was to find out how many women would be interested in a trial involving postmenopausal hormone therapy (PHT) and how the women's background characteristics and opinions correlated to their interest. Methods The data come from recruitment questionnaires (n = 2000) sent to women in Estonia in 1998. A random sample of women aged 45 to 64 was drawn from the Population Registry. The trial is a two-group randomized trial comparing estrogen-progestogen therapy with placebo or no drugs. A brief description of the study was attached to the questionnaires. Women were not told at this stage of the recruitment which group they would be assigned to, however, they were told of the chance to receive either hormone, placebo or no treatment. Results After two reminders, 1312 women (66%) responded. Eleven percent of the women approached (17% of the respondents) were interested in joining the trial, and 8% wanted more information before deciding. When the 225 women who stated clearly that they were interested in joining and the 553 women who said they were not interested were compared, it was found that interested women were younger and, adjusting for age, that more had given birth; in other respects, the sociodemographic characteristics and health habits of the interested women were similar to those of the non-interested women. The interested women had made more use of more health services, calcium preparations and PHT, they were more often overweight, and more had chronic diseases and reported symptoms. Interested women's opinions on the menopause were more negative, and they favoured PHT more than the non-interested women. Conclusion Unlike the situation described in previous reports on preventive trials, in this case Estonian women interested in participating in a PHT trial were not healthier than other women. This suggests that trials involving PHT are more similar to treatment trials than to preventive trials. In a randomized controlled trial, more information should be obtained from those women who decline to participate. -
dc.language.iso en -
dc.title Who wants to join preventive trials? Experience from the Estonian Postmenopausal Hormone Therapy Trial [ISRCTN35338757] -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-646 -
dc.identifier.doi 10.1186/1471-2288-5-12 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Terveystiede | en=Health care science| -
dc.journal.title BMC Medical Research Methodology -
dc.journal.volume 5 -
dc.journal.number 12 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 48 -

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