CRP gene variation affects early development of Alzheimer's disease-related plaques


Näytä suppeat kuvailutiedot Kok, Eloise H - Alanne-Kinnunen, Mervi - Isotalo, Karita - Luoto, Teemu - Haikonen, Satu - Goebeler, Sirkka - Perola, Markus - Hurme, Mikko - Haapasalo, Hannu - Karhunen, Pekka J - 2012-06-17T20:14:21Z 2012-06-15 16:52:35 - 2012-06-17T20:14:21Z 2011 -
dc.identifier.issn 1742-2094 -
dc.description BioMed Central Open access -
dc.description.abstract Introduction We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's disease-related lesions. Methods We studied senile plaque (SP), neurofibrillary tangles (NFT) and SP phenotype associations with 6 reported haplotype tagging single nucleotide polymorphisms (SNPs) in the CRP gene. CRP and Aβ immunohistochemistry was assessed using brain tissue microarrays. Results In multivariate analyses (age- and APOE-adjusted), non-neuritic SP were associated with the high-CRP TA-genotype (3.0% prevalence) of rs3091244 and CA-genotype (10.8%) of rs3093075 compared to common genotypes. Conversely, the low-CRP C allele (39.3%) of rs2794521 reduced the risk of harbouring early non-neuritic SP, compared to the TT genotype. CRP haplotype TAGCC (high) associated with non-neuritic SP, whereas haplotype CCGCC offered protection. TT genotypes (high) of rs3091244 and rs1130864 were associated with CRP staining. There were no associations between SNPs or haplotypes and NFT. CRP staining of the hippocampal CA1/2 region correlated with Aβ staining. Conclusions CRP gene variation affects early SP development in prodromal Alzheimer's disease, independent of APOE genotype. -
dc.language.iso en -
dc.title CRP gene variation affects early development of Alzheimer's disease-related plaques -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-661 -
dc.identifier.doi 10.1186/1742-2094-8-96 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Oikeuslääketiede ja muut lääketieteet | en=Forensic science and other medical sciences| -
dc.administrativeunit fi=Biolääketieteellisen teknologian yksikkö | en=Institute of Biomedical Technology| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Journal of Neuroinflammation -
dc.journal.volume 8 -
dc.journal.number 96 -
dc.journal.volumepagerange 1-9 -
dc.oldstats 55 -

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