Nora Virus Persistent Infections Are Not Affected by the RNAi Machinery


Näytä suppeat kuvailutiedot Habayeb, Mazen S - Ekström, Jens-Ola - Hultmark, Dan - 2012-06-17T20:14:29Z 2012-06-07 11:23:22 - 2012-06-17T20:14:29Z 2009 -
dc.identifier.issn 1932-6203 -
dc.description Public Library Open access -
dc.description.abstract Drosophila melanogaster is widely used to decipher the innate immune system in response to various pathogens. The innate immune response towards persistent virus infections is among the least studied in this model system. We recently discovered a picorna-like virus, the Nora virus which gives rise to persistent and essentially symptom-free infections in Drosophila melanogaster. Here, we have used this virus to study the interaction with its host and with some of the known Drosophila antiviral immune pathways. First, we find a striking variability in the course of the infection, even between flies of the same inbred stock. Some flies are able to clear the Nora virus but not others. This phenomenon seems to be threshold-dependent; flies with a high-titer infection establish stable persistent infections, whereas flies with a lower level of infection are able to clear the virus. Surprisingly, we find that both the clearance of low-level Nora virus infections and the stability of persistent infections are unaffected by mutations in the RNAi pathways. Nora virus infections are also unaffected by mutations in the Toll and Jak-Stat pathways. In these respects, the Nora virus differs from other studied Drosophila RNA viruses. -
dc.language.iso en -
dc.title Nora Virus Persistent Infections Are Not Affected by the RNAi Machinery -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-684 -
dc.identifier.doi 10.1371/journal.pone.0005731 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Lääketieteen bioteknologia | en=Medical biotechnology| -
dc.journal.title PLoS ONE -
dc.journal.volume 4 -
dc.journal.number 5 -
dc.journal.volumepagerange 1-5 -
dc.oldstats 47 -

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