Transcriptome Profiling of Human Pre-Implantation Development


Näytä suppeat kuvailutiedot Zhang, Pu - Zucchelli, Marco - Bruce, Sara - Hambiliki, Fredwell - Stavreus-Evers, Anneli - Levkov, Lev - Skottman, Heli - Kerkelä, Erja - Kere, Juha - Hovatta, Outi - 2012-06-17T20:14:31Z 2012-06-07 11:25:14 - 2012-06-17T20:14:31Z 2009 -
dc.identifier.issn 1932-6203 -
dc.description Public Library of Science -
dc.description.abstract Background Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known. Methodology By applying microarray on 397 human oocytes and embryos at six developmental stages, we studied the transcription dynamics during human preimplantation development. Principal Findings We found that the preimplantation development consisted of two main transitions: from metaphase-II oocyte to 4-cell embryo where mainly the maternal genes were expressed, and from 8-cell embryo to blastocyst with down-regulation of the maternal genes and up-regulation of embryonic genes. Human preimplantation development proved relatively autonomous. Genes predominantly expressed in oocytes and embryos are well conserved during evolution. Significance Our database and findings provide fundamental resources for understanding the genetic network controlling early human development. -
dc.language.iso en -
dc.title Transcriptome Profiling of Human Pre-Implantation Development -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-687 -
dc.identifier.doi 10.1371/journal.pone.0007844 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title PLoS ONE -
dc.journal.volume 4 -
dc.journal.number 11 -
dc.journal.volumepagerange 1-7 -
dc.oldstats 48 -

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