Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

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dc.contributor.author Ryhänen, Tuomas -
dc.contributor.author Viiri, Johanna -
dc.contributor.author Hyttinen, Juha M.T -
dc.contributor.author Uusitalo, Hannu -
dc.contributor.author Salminen, Antero -
dc.contributor.author Kaarniranta, Kai -
dc.date.accessioned 2012-06-17T20:14:36Z
dc.date.available 2012-06-14 15:13:35 -
dc.date.available 2012-06-17T20:14:36Z
dc.date.issued 2011 -
dc.identifier.issn 1110-7243 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65951
dc.description Hindawi open access -
dc.description.abstract Retinal pigment epithelial (RPE) cells are continually exposed to oxidative stress that contributes to protein misfolding, aggregation and functional abnormalities during aging. The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retrograde trafficking to a juxtanuclear location. We demonstrate that Hsp90 inhibition by geldanamycin can effectively suppress proteasome inhibitor, MG-132-induced protein aggregation in a way that is independent of HDAC inhibition or the tubulin acetylation levels in ARPE-19 cells. However, the tubulin acetylation and polymerization state affects the localization of the proteasome-inhibitor-induced aggregation. These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration. -
dc.language.iso en -
dc.title Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-707 -
dc.identifier.doi 10.1155/2011/798052 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Korva-, nenä- ja kurkkutaudit, silmätaudit | en=Otorhinolaryngology, ophthalmology| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Journal of Biomedicine and Biotechnology -
dc.journal.volume 2011 -
dc.journal.number 798052 -
dc.journal.volumepagerange 1-8 -
dc.oldstats 62 -

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