Cardiac Differentiation of Pluripotent Stem Cells


Näytä suppeat kuvailutiedot Rajala, Kristiina - Pekkanen-Mattila, Mari - Aalto-Setälä, Katriina - 2012-06-17T20:14:39Z 2012-06-16 09:21:57 - 2012-06-17T20:14:39Z 2011 -
dc.identifier.issn 1687-9678 -
dc.description Hindawi open access -
dc.description.abstract The ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine. The ultimate goal to repair the heart by cardiomyocyte replacement has, however, proven challenging. Human cardiac differentiation has been difficult to control, but methods are improving, and the process, to a certain extent, can be manipulated and directed. The stem cell-derived cardiomyocytes described to date exhibit rather immature functional and structural characteristics compared to adult cardiomyocytes. Thus, a future challenge will be to develop strategies to reach a higher degree of cardiomyocyte maturation in vitro, to isolate cardiomyocytes from the heterogeneous pool of differentiating cells, as well as to guide the differentiation into the desired subtype, that is, ventricular, atrial, and pacemaker cells. In this paper, we will discuss the strategies for the generation of cardiomyocytes from pluripotent stem cells and their characteristics, as well as highlight some applications for the cells. -
dc.language.iso en -
dc.title Cardiac Differentiation of Pluripotent Stem Cells -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-719 -
dc.identifier.doi 10.4061/2011/383709 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.administrativeunit fi=Biolääketieteellisen teknologian yksikkö | en=Institute of Biomedical Technology| -
dc.journal.title Stem Cells International -
dc.journal.volume 2011 -
dc.journal.number 383709 -
dc.journal.volumepagerange 1-12 -
dc.oldstats 54 -

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