Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis

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dc.contributor.author Päiväniemi, Outi E -
dc.contributor.author Maasilta, Paula K -
dc.contributor.author Vainikka, Tiina LS -
dc.contributor.author Alho, Hanni S -
dc.contributor.author Karhunen, Pekka J -
dc.contributor.author Salminen, Ulla-Stina -
dc.date.accessioned 2012-06-17T20:14:39Z
dc.date.available 2012-06-15 07:00:34 -
dc.date.available 2012-06-17T20:14:39Z
dc.date.issued 2009 -
dc.identifier.issn 1466-1861 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65968
dc.description Hindawi Open access -
dc.description.abstract The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P < .0001) and fibroblasts (P = .02) resulted in occlusion of the bronchial lumens (P < .01). Influx of CD4+ (P < .001) and CD8+ (P < .0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P < .01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R = 0.456–0.879, P < .05−P < .0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P < .05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response. -
dc.language.iso en -
dc.title Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-723 -
dc.identifier.doi 10.1155/2009/510254 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.journal.title Mediators of Inflammation -
dc.journal.volume 2009 -
dc.journal.number 510254 -
dc.journal.volumepagerange 1-7 -
dc.oldstats 48 -

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