Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age

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dc.contributor.author Elfving, Maria -
dc.contributor.author Svensson, Johan -
dc.contributor.author Oikarinen, Sami -
dc.contributor.author Jonsson, Björn -
dc.contributor.author Olofsson, Per -
dc.contributor.author Sundkvist, Göran -
dc.contributor.author Lindberg, Bengt -
dc.contributor.author Lernmark, Åke -
dc.contributor.author Hyöty, Heikki -
dc.contributor.author Ivarsson, Sten-Anders -
dc.date.accessioned 2012-06-17T20:14:40Z
dc.date.available 2012-06-15 14:54:18 -
dc.date.available 2012-06-17T20:14:40Z
dc.date.issued 2008 -
dc.identifier.issn 1687-5303 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65969
dc.description Hindawi Open access -
dc.description.abstract Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring’s risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulinM(IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22– 17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood. -
dc.language.iso en -
dc.title Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-724 -
dc.identifier.doi 10.1155/2008/271958 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title Experimental Diabetes Research -
dc.journal.volume 2008 -
dc.journal.number 271958 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 55 -

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