COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study

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dc.contributor.author Huuskonen, Kati H -
dc.contributor.author Kunnas, Tarja A -
dc.contributor.author Tanner, Minna M -
dc.contributor.author Mikkelsson, Jussi -
dc.contributor.author Ilveskoski, Erkki -
dc.contributor.author Karhunen, Pekka J -
dc.contributor.author Nikkari, Seppo T -
dc.date.accessioned 2012-06-17T20:14:41Z
dc.date.available 2012-06-15 06:40:57 -
dc.date.available 2012-06-17T20:14:41Z
dc.date.issued 2008 -
dc.identifier.issn 1466-1861 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65972
dc.description Hindawi Open access -
dc.description.abstract Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G → C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was quantitated, and coronary narrowing wasmeasured. The occurrence ofmyocardial infarction (MI) was assessed. Genotyping was by restriction endonuclease analysis. Men carrying the minor C allele had larger areas of complicated lesions (P = .024) and a higher number of coronary arteries that had over 50% stenosis (P = .036) compared to men representing the common GG genotype. The COX-2 polymorphism was not associated with MI. Our data suggest that COX-2 may be involved in plaque growth. -
dc.language.iso en -
dc.title COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-727 -
dc.identifier.doi 10.1155/2008/289453 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title Mediators of Inflammation -
dc.journal.volume 2008 -
dc.journal.number 289453 -
dc.journal.volumepagerange 1-5 -
dc.oldstats 59 -

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