JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages

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dc.contributor.author Sareila, Outi -
dc.contributor.author Korhonen, Riku -
dc.contributor.author Kärpänniemi, Outi -
dc.contributor.author Nieminen, Riina -
dc.contributor.author Kankaanranta, Hannu -
dc.contributor.author Moilanen, Eeva -
dc.date.accessioned 2012-06-17T20:14:42Z
dc.date.available 2012-06-15 20:41:42 -
dc.date.available 2012-06-17T20:14:42Z
dc.date.issued 2006 -
dc.identifier.issn 1466-1861 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65976
dc.description Hindawi Open access -
dc.description.abstract In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression and NO production in J774 murine macrophages stimulated with interferon-γ (IFN-γ).     JAK inhibitors AG-490 andWHI-P154 decreased IFN-γ-induced nuclear levels of signal transducer and activator of transcription 1α (STAT1α). JAK inhibitors AG-490 and WHI-P154 decreased also iNOS protein and mRNA expression and NO production in a concentration-dependentmanner. Neither of the JAK inhibitors affected the decay of iNOS mRNA when determined by actinomycin D assay. Our results suggest that the inhibition of JAKSTAT1-pathway by AG-490 or WHI-P154 leads to the attenuation of iNOS expression and NO production in IFN-γ-stimulated macrophages. -
dc.language.iso en -
dc.title JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-733 -
dc.identifier.doi 10.1155/MI/2006/16161 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Farmasia | en=Pharmacy| -
dc.journal.title Mediators of Inflammation -
dc.journal.volume 2006 -
dc.journal.number 16161 -
dc.journal.volumepagerange 1-7 -
dc.oldstats 69 -

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