Lactase non-persistent genotype influences milk consumption and gastrointestinal symptoms in Northern Russians

TamPub

Näytä suppeat kuvailutiedot

dc.contributor.author Khabarova, Yulia -
dc.contributor.author Torniainen, Suvi -
dc.contributor.author Tuomisto, Sari -
dc.contributor.author Järvelä, Irma -
dc.contributor.author Karhunen, Pekka J -
dc.contributor.author Isokoski, Mauri -
dc.contributor.author Mattila, Kari -
dc.date.accessioned 2012-06-17T20:14:46Z
dc.date.available 2012-06-16 09:25:49 -
dc.date.available 2012-06-17T20:14:46Z
dc.date.issued 2011 -
dc.identifier.issn 1471-230X -
dc.identifier.uri http://tampub.uta.fi/handle/10024/65995
dc.description BioMed Central Open access -
dc.description.abstract Background Milk is an important source of nutrients. The consumption of milk, however, may cause abdominal complaints in lactose intolerant individuals. The frequency of -13910C/C genotype is known to be high among Northern Russians, exceeding the prevalence in northern Europe. In our study we tested two hypotheses: 1) subjects with lactase non-persistent genotype (-13910C/C) have more gastrointestinal (GI) symptoms associated with milk 2) subjects with lactase non-persistence avoid using milk. Methods In total, 518 students aged 17 to 26 years were randomly selected from different departments in the Northern State Medical University (NSMU) for genotyping the lactase activity-defining -13910C/T variant. All subjects filled in a questionnaire covering their personal data, self-reported GI symptoms and milk consumption habits. Results Northern Russians consume very small amounts of milk daily. Among carriers of the lactase non-persistent (LNP) genotype there were 10 percentage units of milk-consumers fewer than among lactase-persistent (LP) subjects (p = 0.03). Complaints of GI disorders caused by milk were different between the genotypes (p = 0.02). Among all types of food analyzed only milk was associated with increased GI symptoms among subjects with the LNP genotype (OR =1.95, CI 1.03-3.69) Conclusions Subjects with -13910C/C have more GI symptoms from milk. Subjects with lactase non-persistent genotype avoid using milk. In the case of increasing milk consumption symptoms may increase the need for medical consultation. It is thus important either for people themselves or for health care staff to be aware of lactase persistence/non-persistence. -
dc.language.iso en -
dc.title Lactase non-persistent genotype influences milk consumption and gastrointestinal symptoms in Northern Russians -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-750 -
dc.identifier.doi 10.1186/1471-230X-11-124 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title BMC Gastroenterology -
dc.journal.volume 11 -
dc.journal.number 124 -
dc.journal.volumepagerange 1-20 -
dc.oldstats 54 -

Viite kuuluu kokoelmiin:

Näytä suppeat kuvailutiedot