Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells

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dc.contributor.author Marttila, Saara -
dc.contributor.author Jylhävä, Juulia -
dc.contributor.author Eklund, Carita -
dc.contributor.author Hervonen, Antti -
dc.contributor.author Jylhä, Marja -
dc.contributor.author Hurme, Mikko -
dc.date.accessioned 2012-06-17T20:15:21Z
dc.date.available 2012-06-16 09:00:00 -
dc.date.available 2012-06-17T20:15:21Z
dc.date.issued 2011 -
dc.identifier.issn 1742-4933 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66078
dc.description.abstract Background Old age is associated with increased levels of circulating pro-inflammatory cytokines, a phenomenon termed inflamm-aging. Elevated levels of pro-inflammatory cytokines have been associated with several age-associated diseases and with a shortened lifespan. Indoleamine 2,3-dioxygenase (IDO) has immunomodulatory properties and its activity is elevated in inflammation, autoimmune disorders and malignancies. We have previously shown that IDO activity is increased in nonagenarians compared to young individuals and that high IDO activity is associated with mortality at old age. Findings In this study our aim was to assess whether this difference in IDO activity in the plasma was due to the differential expression of either the IDO1 or IDO2 gene in peripheral blood mononuclear cells. Our results show that IDO1 and IDO2 are not differently expressed in nonagenarians compared to controls and that the expression of IDO genes is not associated with the level of IDO activity in the plasma. Conclusion The level of IDO activity in the plasma is not regulated through the expression of IDO1 or IDO2 in the peripheral blood mononuclear cells. -
dc.language.iso en -
dc.title Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-493 -
dc.identifier.doi 10.1186/1742-4933-8-9 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Sisätaudit | en=Internal Medicine| -
dc.administrativeunit fi=Terveystieteiden yksikkö | en=School of Health Sciences| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Immunity & Ageing -
dc.journal.volume 8 -
dc.journal.number 9 -
dc.journal.volumepagerange 1-4 -
dc.oldstats 75 -

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