Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis : a case-control study

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dc.contributor.author Luukkainen, Annika -
dc.contributor.author Karjalainen, Jussi -
dc.contributor.author Honkanen, Teemu -
dc.contributor.author Lehtonen, Mikko -
dc.contributor.author Paavonen, Timo -
dc.contributor.author Toppila-Salmi, Sanna -
dc.date.accessioned 2012-06-17T20:15:28Z
dc.date.available 2012-06-14 07:56:29 -
dc.date.available 2012-06-17T20:15:28Z
dc.date.issued 2011 -
dc.identifier.issn 2045-7022 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66090
dc.description BioMed Central open access -
dc.description.abstract Background Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. Objective Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis patients allergic to birch pollen during peak exposure to birch pollen allergen and compare it to non-atopic patients. Methods IDO expression was immunohistochemically evaluated from nasal specimens obtained in- and off-season from otherwise healthy non-smoking volunteers both allergic to birch pollen (having mild or moderate allergic rhinoconjunctivitis) and non-allergic controls. Results: The IDO expression levels were low in healthy controls and remained low also in patients allergic to birch pollen. There were no differences in the expression of IDO in- and off-season in either healthy or allergic subjects. Conclusions There is a controversy in the role of IDO in upper and lower airways during allergic airway disease. It seems that IDO is associated to allergic inflammations of the lower airways, but does not have a local role in the nasal cavity at least in mild or moderate forms of allergic rhinitis. Keywords: Indoleamine 2,3-dioxygenase; allergic rhinitis; birch pollen; dendritic cell; tryptophan; kynurenine; interferon gamma; leukocyte; eosinophil -
dc.language.iso en -
dc.title Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis : a case-control study -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-932 -
dc.identifier.doi 10.1186/2045-7022-1-17 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Korva-, nenä- ja kurkkutaudit, silmätaudit | en=Otorhinolaryngology, ophthalmology| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Clinical and translational allergy -
dc.journal.volume 1 -
dc.journal.number 17 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 46 -

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