Antibody to P.falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use

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dc.contributor.author Aitken, Elizabeth -
dc.contributor.author Mbewe, Bernard -
dc.contributor.author Luntamo, Mari -
dc.contributor.author Kulmala, Teija -
dc.contributor.author Beeson, James -
dc.contributor.author Ashorn, Per -
dc.contributor.author Rogerson, Stephen -
dc.date.accessioned 2012-06-17T20:15:37Z
dc.date.available 2012-06-16 08:44:30 -
dc.date.available 2012-06-17T20:15:37Z
dc.date.issued 2012 -
dc.identifier.issn 1932-6203 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66101
dc.description Public Library of Science -
dc.description.abstract Background Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development. Methods and Findings: Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae. Conclusions/Significance Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity. -
dc.language.iso en -
dc.title Antibody to P.falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-956 -
dc.identifier.doi 10.1371/journal.pone.0029874.t001 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Plos ONE -
dc.journal.volume 7 -
dc.journal.number 1 -
dc.journal.volumepagerange 1-4 -
dc.oldstats 28 -

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