Study protocol for prevention of falls: A randomized controlled trial of effects of vitamin D and exercise on falls prevention


Näytä suppeat kuvailutiedot Uusi-Rasi, Kirsti - Kannus, Pekka - Karinkanta, Saija - Pasanen, Matti - Patil, Radhika - Lamberg-Allardt, Christel - Sievänen, Harri - 2012-06-17T20:15:44Z 2012-06-14 20:41:22 - 2012-06-17T20:15:44Z 2012 -
dc.identifier.issn 1471-2318 -
dc.description BioMed Center open access -
dc.description.abstract Background Falls are the leading cause of unintentional injury and injury-related death among older people. In addition to physical activity, vitamin D also may affect balance and neuromuscular function. Low serum 25-hydroksivitamin D level increases the risk of bone loss, falls and fractures. Thus, an appropriate exercise program and sufficient vitamin D intake may significantly improve not only functional balance, but also balance confidence. Balance represents a complex motor skill determined by reaction time, muscle strength, and speed and coordination of movement. Methods/Design A 2-year randomized double-blind placebo-controlled vitamin D and open exercise trial of 409 home-dwelling women 70 to 80 years of age comprising four study arms: 1) exercise + vitamin D (800 IU/d), 2) exercise + placebo, 3) no exercise + vitamin D (800 IU/d), 4) no exercise + placebo. In addition to monthly fall diaries, general health status, life style, bone health, physical functioning, and vitamin D metabolism will be assessed. The primary outcomes are the rate of falls and fall-related injuries. Secondary outcomes include changes in neuromuscular functioning (e.g. body balance, muscle strength), ADL- and mobility functions, bone density and structure, cardiovascular risk factors, quality of life and fear of falling. Discussion The successful completion of this trial will provide evidence on the effectiveness of exercise and vitamin D for falls reduction. -
dc.language.iso en -
dc.title Study protocol for prevention of falls: A randomized controlled trial of effects of vitamin D and exercise on falls prevention -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-994 -
dc.identifier.doi doi:10.1186/1471-2318-12-12 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Oikeuslääketiede ja muut lääketieteet | en=Forensic science and other medical sciences| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title BMC Geriatrics -
dc.journal.volume 12 -
dc.journal.number 12 -
dc.journal.volumepagerange 1-7 -
dc.oldstats 24 -

Viite kuuluu kokoelmiin:

Näytä suppeat kuvailutiedot