Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma

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dc.contributor.author Ronkainen, Hanna -
dc.contributor.author Hirvikoski, Pasi -
dc.contributor.author Kauppila, Saila -
dc.contributor.author Vuopala, Katri S -
dc.contributor.author Paavonen, Timo -
dc.contributor.author Selander, Katri -
dc.date.accessioned 2012-06-17T20:15:48Z
dc.date.available 2012-06-08 16:17:42 -
dc.date.available 2012-06-17T20:15:48Z
dc.date.issued 2011 -
dc.identifier.issn 0392-9078 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66134
dc.description BMC -
dc.description.abstract Background Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to examine the expression of TLR9 in renal cell carcinoma (RCC), which is generally renowned of its immunogenic nature. We also evaluated the prognostic value of TLR9 in RCC. Methods TLR9 expression in RCC was characterized with immunohistochemistry in a retrospective study population of 152 RCC patients who underwent renal surgery. The TLR9 staining intensity was compared with clinical parameters. Results Of the studied tumours, 112 (81%) exhibited cytoplasmic TLR9 immunostaining. No association was detected between cytoplasmic TLR9 immunoexpression intensity and stage, nuclear grade, histological subtype or tumour necrosis. Cytoplasmic TLR9 immunoexpression was, however, a marker of favourable RCC specific survival both in univariate analysis and in multivariate regression model. Conclusions We conclude that TLR9 expression is an independent prognostic marker of RCC and the absence of TLR9 expression is related to poorer prognosis in RCC. Keywords: renal cell carcinoma; toll-like receptor 9; tumour necrosis; prognosis -
dc.language.iso en -
dc.title Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-498 -
dc.identifier.doi 10.1186/1756-9966-30-84 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.administrativeunit fi=Lääketieteen yksikkö | en=School of Medicine| -
dc.journal.title Journal of Experimental & Clinical Cancer Research -
dc.journal.volume 30 -
dc.journal.number 84 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 86 -

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