Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial

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dc.contributor.author Luoto, Riitta -
dc.contributor.author Kharazmi, Elham -
dc.contributor.author Saarinen, Niina M -
dc.contributor.author Smeds, Annika I -
dc.contributor.author Mäkelä, Sari -
dc.contributor.author Fallah, Mahdi -
dc.contributor.author Raitanen, Jani -
dc.contributor.author Hilakivi-Clarke, Leena -
dc.date.accessioned 2012-06-17T20:16:06Z
dc.date.available 2012-06-06 14:47:10 -
dc.date.available 2012-06-17T20:16:06Z
dc.date.issued 2010 -
dc.identifier.issn 1742-4755 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66189
dc.description BioMed Central Open access -
dc.description.abstract Background Mother's diet during pregnancy is important, since plant lignans and their metabolites, converted by the intestinal microflora to enterolignans, are proposed to possess multiple health benefits. Aim of our study was to investigate whether a dietary intervention affects lignan concentrations in the serum of pregnant women. Methods A controlled dietary intervention trial including 105 first-time pregnant women was conducted in three intervention and three control maternity health clinics. The intervention included individual counseling on diet and on physical activity, while the controls received conventional care. Blood samples were collected on gestation weeks 8-9 (baseline) and 36-37 (end of intervention). The serum levels of the plant lignans 7-hydroxymatairesinol, secoisolariciresinol, matairesinol, lariciresinol, cyclolariciresinol, and pinoresinol, and of the enterolignans 7-hydroxyenterolactone, enterodiol, and enterolactone, were measured using a validated method. Results The baseline levels of enterolactone, enterodiol and the sum of lignans were higher in the control group, whereas at the end of the trial their levels were higher in the intervention group. The adjusted mean differences between the baseline and end of the intervention for enterolactone and the total lignan intake were 1.6 ng/ml (p = 0.018, 95% CI 1.1-2.3) and 1.4 ng/mg (p = 0.08, 95% CI 1.0-1.9) higher in the intervention group than in the controls. Further adjustment for dietary components did not change these associations. Conclusion The dietary intervention was successful in increasing the intake of lignan-rich food products, the fiber consumption and consequently the plasma levels of lignans in pregnant women. -
dc.language.iso en -
dc.title Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-502 -
dc.identifier.doi 10.1186/1742-4755-7-26 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Terveystiede | en=Health care science| -
dc.journal.title Reproductive Health -
dc.journal.volume 7 -
dc.journal.number 26 -
dc.journal.volumepagerange 1-6 -
dc.oldstats 63 -

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