The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

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dc.contributor.author Nordfors, Kristiina -
dc.contributor.author Haapasalo, Joonas -
dc.contributor.author Korja, Miikka -
dc.contributor.author Parkkila, Seppo (Tay) -
dc.date.accessioned 2012-06-17T20:16:32Z
dc.date.available 2012-06-16 10:47:50 -
dc.date.available 2012-06-17T20:16:32Z
dc.date.issued 2010 -
dc.identifier.issn 1471-2407 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66265
dc.description BioMed Central Open access -
dc.description.abstract Background Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there are only few known biomarkers or therapeutic target proteins, and the prognosis of patients with these tumours remains poor. Our aim was to investigate whether carbonic anhydrases (CAs), enzymes commonly overexpressed in various tumours including glioblastomas and oligodendrogliomas, are present in MBs and PNETs, and whether their expression can be correlated with patient prognosis. Methods We determined the expression of the tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a series of MB/PNET specimens (n = 39) using immunohistochemistry. Results Endothelial CA II, cytoplasmic CA II, CA IX and CA XII were expressed in 49%, 73%, 23% and 11% of the tumours, respectively. CA II was detected in the neovessel endothelium and the tumour cell cytoplasm. CA IX was mainly expressed in the tumour cells located in perinecrotic areas. CA XII showed the most homogenous distribution within the tumours. Importantly, CA IX expression predicted poor prognosis in both univariate (p = 0.041) and multivariate analyses (p = 0.016). Conclusions We suggest that CA IX should be considered a potential prognostic and therapeutic target in MBs and PNETs. -
dc.language.iso en -
dc.title The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-529 -
dc.identifier.doi 10.1186/1471-2407-10-148 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title BMC Cancer -
dc.journal.volume 10 -
dc.journal.number 148 -
dc.journal.volumepagerange 1-10 -
dc.oldstats 69 -

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