Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model

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dc.contributor.author Gassas, Adam -
dc.contributor.author Min, Weixian -
dc.contributor.author Evans, A Wayne -
dc.contributor.author Carter, Susan -
dc.contributor.author Sándor, George K -
dc.contributor.author Grunebaum, Eyal -
dc.date.accessioned 2012-06-17T20:16:32Z
dc.date.available 2012-06-17 02:41:00 -
dc.date.available 2012-06-17T20:16:32Z
dc.date.issued 2011 -
dc.identifier.issn 2090-3006 -
dc.identifier.uri http://tampub.uta.fi/handle/10024/66266
dc.description Hindawi Open access -
dc.description.abstract Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated skin graft rejection. Methods. C57/BL6 black-coated (H2B) mice received skin graft from CBA (H2D) white-coated mice. Mice were treated with either 19 session of 240 kpa oxygen or 29 session of 300 kpa oxygen, for 90 minutes. Mice were housed either 4 per cage or separately, to prevent friction and mechanical factors that may affect graft survival. Skin grafts were assessed daily. Results. There was no difference in length of graft survival between mice that received either regimens of HBO therapy and mice that did not receive HBO therapy. Conclusions. HBO therapy, as a sole agent, did not delay skin graft rejection in a highly immunogenic mouse model. -
dc.language.iso en -
dc.title Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-720 -
dc.identifier.doi 10.1155/2011/579268 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.administrativeunit fi=Biolääketieteellisen teknologian yksikkö | en=Institute of Biomedical Technology| -
dc.journal.title Bone Marrow Research -
dc.journal.volume 2011 -
dc.journal.number 579268 -
dc.journal.volumepagerange 1-3 -
dc.oldstats 53 -

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