Non-Hodgkin lymphoma response evaluation with MRI texture classification


Näytä suppeat kuvailutiedot Pertovaara, Hannu - Heinonen, Tomi T - Järvenpää, Ritva - Harrison, Lara CV (Tay) - Luukkaala, Tiina (Tay) - Saarinen, Tuomas O (Tay) - Soimakallio, Seppo (Tay) - Kellokumpu-Lehtinen, Pirkko-Liisa (Tay) - Dastidar, Prasun (Tay) - 2012-06-17T20:16:40Z 2012-06-15 07:18:00 - 2012-06-17T20:16:40Z 2009 -
dc.identifier.issn 1756-9966 -
dc.description BioMed Central Open access -
dc.description.abstract Background To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis. Methods A total of 19 patients having NHL with an evaluable lymphoma lesion were scanned at three imaging timepoints with 1.5T device during clinical treatment evaluation. Texture characteristics of images were analyzed and classified with MaZda application and statistical tests. Results NHL tissue MRI texture imaged before treatment and under chemotherapy was classified within several subgroups, showing best discrimination with 96% correct classification in non-linear discriminant analysis of T2-weighted images. Texture parameters of MRI data were successfully tested with statistical tests to assess the impact of the separability of the parameters in evaluating chemotherapy response in lymphoma tissue. Conclusion Texture characteristics of MRI data were classified successfully; this proved texture analysis to be potential quantitative means of representing lymphoma tissue changes during chemotherapy response monitoring. -
dc.language.iso en -
dc.title Non-Hodgkin lymphoma response evaluation with MRI texture classification -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-551 -
dc.identifier.doi 10.1186/1756-9966-28-87 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Syöpätaudit | en=Cancers| -
dc.journal.title Journal of Experimental & Clinical Cancer Research -
dc.journal.volume 28 -
dc.journal.number 87 -
dc.journal.volumepagerange 1-13 -
dc.oldstats 70 -

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