Expression of iron-related genes in human brain and brain tumors


Näytä suppeat kuvailutiedot Hänninen, Milla M - Haapasalo, Joonas - Haapasalo, Hannu - Fleming, Robert E - Britton, Robert S - Bacon, Bruce R - Parkkila, Seppo - 2012-06-17T20:16:40Z 2012-06-17 00:27:20 - 2012-06-17T20:16:40Z 2009 -
dc.identifier.issn 1471-2202 -
dc.description BioMed Central Open access -
dc.description.abstract Background Defective iron homeostasis may be involved in the development of some diseases within the central nervous system. Although the expression of genes involved in normal iron balance has been intensively studied in other tissues, little is known about their expression in the brain. We investigated the mRNA levels of hepcidin (HAMP), HFE, neogenin (NEO1), transferrin receptor 1 (TFRC), transferrin receptor 2 (TFR2), and hemojuvelin (HFE2) in normal human brain, brain tumors, and astrocytoma cell lines. The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines. Results Except for hemojuvelin, all genes studied had detectable levels of mRNA. In most tumor types, the pattern of gene expression was diverse. Notable findings include high expression of transferrin receptor 1 in the hippocampus and medulla oblongata compared to other brain regions, low expression of HFE in normal brain with elevated HFE expression in meningiomas, and absence of hepcidin mRNA in astrocytoma cell lines despite expression in normal brain and tumor specimens. Conclusion These results indicate that several iron-related genes are expressed in normal brain, and that their expression may be dysregulated in brain tumors. -
dc.language.iso en -
dc.title Expression of iron-related genes in human brain and brain tumors -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal article| -
dc.identifier.urn urn:nbn:uta-3-553 -
dc.identifier.doi 10.1186/1471-2202-10-36 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Biolääketieteet | en=Biomedicine| -
dc.journal.title BMC Neuroscience -
dc.journal.volume 10 -
dc.journal.number 36 -
dc.journal.volumepagerange 1-9 -
dc.oldstats 45 -

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