The effect of hormone therapy on women's quality of life in the first year of the Estonian Postmenopausal Hormone Therapy trial


Näytä suppeat kuvailutiedot Veerus, Piret Hovi, Sirpa-Liisa Sévon, Tiina Hunter, Myra Hemminki, Elina 2012-08-07T07:07:53Z 2012-08-07T07:07:53Z 2012
dc.identifier.issn 1756-0500 -
dc.description BioMed Central open access -
dc.description.abstract Background For postmenopausal women, the main reason to start hormone therapy (HT) is to reduce menopausal symptoms and to improve quality of life (QOL). The aim of this study was to analyse the impact of HT on different aspects of symptom experience and QOL during a randomised trial. A total of 1823 postmenopausal women were recruited into the Estonian Postmenopausal Hormone Therapy (EPHT) trial in 1999–2001. Women were randomised to blind HT, open-label HT, placebo or non-treatment arm. After one year in the trial, a questionnaire was mailed and 1359 women (75%) responded, 686 in the HT arms and 673 in the non-HT arms. Mean age at filling in the questionnaire was 59.8 years. The questionnaire included Women's Health Questionnaire (WHQ) to assess menopause specific QOL of middle-aged women together with a 17-item questionnaire on symptoms related to menopause, a question about painful intercourse, and a question about women's self-rated health. Results After one year in the trial, fewer women in the HT arms reported hot flashes, trouble sleeping, and sweating on the symptom questionnaire. According to WHQ, women in the HT arms had fewer vasomotor symptoms, sleep problems, and problems with sexual behaviour, but more menstrual symptoms; HT had no effect on depression, somatic symptoms, memory, attractiveness, or anxiety. A smaller proportion of women reported painful intercourse in the HT arms. There were no significant differences between the trial arms in women’s self-rated subjective health. Conclusions The results from the EPHT trial confirm that HT is not justified for treating symptoms, other than vasomotor symptoms, among postmenopausal women. WHQ proved to be a useful and sensitive tool to assess QOL in this age group of women. -
dc.language.iso en -
dc.title The effect of hormone therapy on women's quality of life in the first year of the Estonian Postmenopausal Hormone Therapy trial -
dc.type fi=Artikkeli aikakauslehdessä | en=Journal Article| -
dc.identifier.urn URN:NBN:fi:uta-201208071024 -
dc.identifier.doi doi:10.1186/1756-0500-5-176 -
dc.type.version fi=Kustantajan versio | en=Publisher's version| -
dc.subject.okm fi=Naisten- ja lastentaudit | en=Gynaecology and paediatrics| -
dc.administrativeunit fi=Terveystieteiden yksikkö | en=School of Health Sciences| -
dc.journal.title BMC Research Notes -
dc.journal.volume 5 -
dc.journal.number 176 -
dc.journal.volumepagerange 1-6 -
dc.journal.url -

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