MARK-AGE biomarkers of ageing
Bürkle, Alexander; Moreno-Villanueva, María; Bernhard, Jürgen; Hervonen, Antti; Hurme, Mikko (2015)
Hurme, Mikkoet al.
Mechanisms of Ageing and Development 151
Julkaisun pysyvä osoite on
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
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